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What does prometrium help with? In women who are not pregnant and not going through menopause, this medication is used to restore normal menstrual periods that have stopped for several months (amenorrhea). Progesterone is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms (e.g., hot flashes). How do you take Prometrium? Prometrium is a capsule you take by mouth once a day. Your doctor may recommend you take Prometrium at bedtime, as it can sometimes cause dizziness. If you use Prometrium to prevent uterine cancer while you're on estrogen hormone replacement therapy, you'll take 200 milligrams daily for 12 days in a row.
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