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When should I take allergy medicine? "Once-daily antihistamines reach their peak efficacy 8 to 12 hours after you take them, so using them at dinnertime or before bed means better control of your daytime symptoms," says Yoon Mi Kim, DO, an allergy and immunology specialist for Geisinger. Can I take 2 antihistamines? Some antihistamines may work better than others for your symptoms. It can be hard to find the one that works just right. Do NOT take two different antihistamines at the same time. Instead, talk to your doctor or pharmacist if you have trouble finding a drug that works well for your allergy symptoms. Is it safe to take Zyrtec and Claritin together? Drug interactions Both Zyrtec and Claritin may make you drowsy or tired. For that reason, you shouldn't take these medications if you also take muscle relaxers, sleeping pills, or other drugs that cause drowsiness. Taking them at the same time that you take sedating drugs can make you extremely sleepy.
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